2019 ASCCP Risk-Based Management Consensus Guidelines for abnormal cervical cancer screening tests and cancer precursors. This article explains risk-based management tables under 5 different clinical scenarios that comprise most management visits and decisions. The column named “Recommendation confidence score, %” indicates the percent probability that the KPNC risk estimates fall within the risk range dictating the recommended management (based on the sample size and how close the estimated risks are to clinical action thresholds, Cheung et al.3). The risk remains higher for treated CIN 3 compared with CIN 2 scenarios. The National Cancer Institute (including M.S. 11:10 AM – 11:35 AM: The Clinical Power of Updated Management Guidelines: Personalized Management of Your Patients. Cheung LC, Egemen D, Chen X, et al. Patient 6: A 32-year-old woman has a history of CIN 3 that was treated with a diagnostic excisional procedure (loop electrosurgical excision procedure). In addition, HPV-negative ASC-US and HPV-negative LSIL after HPV-positive NILM are recommended to have a deferred management of 1-year surveillance (see Table 2C). The following column “Recommended management” gives the recommendation for clinical management based on the clinical action thresholds decided by the consensus group. The immediate and 5-year risks of CIN 3+ used to decide clinical management are shown. The risk estimates are in the public domain in the United States of America and are made freely available elsewhere. Table 4B describes CIN 3+ risks when the index cotest was high grade (i.e., ASC-H, AGC, HSIL+). Though higher risk than HPV-negative ASC-US, HPV-negative LSIL is less risky than previously thought, allowing minor abnormalities after HPV-negative LSIL (i.e., HPV-negative ASC-US, HPV-negative LSIL, and HPV-positive NILM) to be followed in 1 year, rather than proceed immediately to colposcopy (see Table 2B). A study of partial human papillomavirus genotyping in support of the 2019 ASCCP risk-based management consensus guidelines. J Low Genit Tract Dis 2020;24:102–31. In Table 4B, “history” again refers to both the colposcopy result (
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